IBS is known as a gut-brain disorder. This means that it originates from a dysfunction in the gut-brain axis (GBA), which is a bi-directional communication pathway between the gut (including intestinal effector cells, the gut microbiome, and the enteric nerves) and the brain (including the central and autonomic nervous systems). Evidence that IBS is a gut-brain illness is apparent in the non-gastrointestinal symptoms reported in a substantial amount of IBS patients. Anxiety and depression precede IBS in some patients, while others develop pschological disorders after the onset of their IBS.
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